tag:blogger.com,1999:blog-35997458635844014.post757138242502784251..comments2023-04-09T09:54:31.911-04:00Comments on Cancer Stem Cell News: Tumorigenic cells not rare in human melanomaJim Tillhttp://www.blogger.com/profile/02092503335133096747noreply@blogger.comBlogger8125tag:blogger.com,1999:blog-35997458635844014.post-79691198805563997422009-01-12T15:39:00.000-05:002009-01-12T15:39:00.000-05:00See also: U-M scientists probe limits of 'cancer s...See also: <A HREF="http://www.youtube.com/watch?v=6a63JJNYKC8" REL="nofollow">U-M scientists probe limits of 'cancer stem-cell model'</A>, YouTube Video [2.31 min], December 4, 2008.Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-74083516488802802682009-01-01T19:50:00.000-05:002009-01-01T19:50:00.000-05:00See also this post: The CSC hypothesis: recalling ...See also this post: <A HREF="http://cancerstemcellnews.blogspot.com/2008/12/csc-hypothesis-recalling-some-history.html" REL="nofollow">The CSC hypothesis: recalling some history</A>, <EM>Cancer Stem Cell News</EM>, December 30, 2008.Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-67165881863082709182008-12-28T14:41:00.000-05:002008-12-28T14:41:00.000-05:00Another commentary: Cancer stem cells: Common as m...Another commentary: <A HREF="http://dx.doi.org/10.1038/nrc2563" REL="nofollow">Cancer stem cells: Common as muck</A> by Safia Ali Danovi, <EM>Nature Reviews Cancer</EM> 2009(Jan); 9(1), 6-7. Excerpt: <EM>Recent data from Sean Morrison and colleagues provide ammunition for the naysayers</EM>. [There's toll-free access to the <A HREF="http://www.nature.com/nrc/journal/v9/n1/full/nrc2563.html" REL="nofollow">full text</A> (free registration is required)].Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-2381233890855324292008-12-27T20:36:00.000-05:002008-12-27T20:36:00.000-05:00For two recent publicly accessible reviews about C...For two recent publicly accessible reviews about CSC and melanoma [written prior to the publication of <A HREF="http://www.ncbi.nlm.nih.gov/pubmed/19052619" REL="nofollow">Efficient tumour formation by single human melanoma cells</A> in <EM>Nature</EM> 2008(Dec 4); 456(7222): 593-8], see: <A HREF="http://tillje.wordpress.com/2008/12/28/oa-reviews-about-cancer-stem-cells-and-melanoma/" REL="nofollow">OA reviews about cancer stem cells and melanoma</A>, <EM>Be openly accessible or be obscure</EM>, December 28, 2008.Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-17450031345342376032008-12-26T20:30:00.000-05:002008-12-26T20:30:00.000-05:00See also: Tweaking and Testing Cancer Stem Cell Mo...See also: <A HREF="http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_121608/page9" REL="nofollow">Tweaking and Testing Cancer Stem Cell Models</A>, Spotlight section, <EM>NCI Cancer Bulletin</EM> 2008(Dec 16); 5(25). Excerpt: <BR/><BR/><EM>Tumors do not grow in a vacuum, she [Dr. Connie Eaves] continued, and few grow in the complete absence of host immune components. "So it is not yet clear that going to extraordinary lengths to promote human tumor growth in a mouse will ultimately be the best test of what propagates a tumor in a person," she said.</EM>Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-29484135157132169372008-12-23T15:59:00.000-05:002008-12-23T15:59:00.000-05:00Another relevant post: Cancer stem cells: controve...Another relevant post: <A HREF="http://blogs.nature.com/reports/theniche/2008/12/cancer_stem_cells_controversie.html" REL="nofollow">Cancer stem cells: controversies and misconceptions</A>, Monya Baker, <EM>The Niche: the stem cell blog</EM>, December 18, 2008. Excerpts: <BR/><BR/><EM>Nature recently published a paper by Sean Morrison and others finding that melanoma stem cells are not rare and that standard assays to identify tumorigenic cells fail to detect a large portion of them. This prompted</EM> [some correspondence].....<BR/><BR/><EM>Here, we publish that correspondence along with replies from David Taussig, which describes evidence for that cancer stem cell hypothesis, including his own evidence that leukemia-initiating cells are less than 1 in 100 cells. Finally, a reply by John Dick and colleagues says that the effects described by Taussig do not apply to a key leukemogenic cell marker and goes on to describe misconceptions about the cancer stem cell model.</EM>Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-30408980307437335372008-12-10T11:17:00.000-05:002008-12-10T11:17:00.000-05:00A publicly-accessible News Feature: Cancer stem ce...A publicly-accessible News Feature: <A HREF="http://www.nature.com/stemcells/2008/0812/081203/full/stemcells.2008.153.html" REL="nofollow">Cancer stem cells, becoming common</A>, Monya Baker, <EM>Nature Reports Stem Cells</EM>, December 3, 2008. Excerpt:<BR/><BR/>[William] <EM>Matsui found that patients with tumours whose invasive margin contained this marker</EM> [ALDH, an enzyme highly expressed in blood-forming and neural stem cells] <EM>survived, on average, four months less than those whose tumours did not. Other groups have also reported a correlation with stem cell markers or gene expression and shorter life expectancy.[<A HREF="http://www.nature.com/stemcells/2008/0812/081203/full/stemcells.2008.153.html#B9" REL="nofollow">9</A>, <A HREF="http://www.nature.com/stemcells/2008/0812/081203/full/stemcells.2008.153.html#B10" REL="nofollow">10</A>, <A HREF="http://www.nature.com/stemcells/2008/0812/081203/full/stemcells.2008.153.html#B11" REL="nofollow">11</A>]</EM>.<BR/><BR/>One could argue that, from a translational-research perspective, associations with clinical outcome are the most meaningful assessments that should be made.Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.comtag:blogger.com,1999:blog-35997458635844014.post-51393005585683859752008-12-06T19:57:00.000-05:002008-12-06T19:57:00.000-05:00See also: Cancer stem cells: Here, there, everywhe...See also: <A HREF="http://dx.doi.org/10.1038/456581a" REL="nofollow">Cancer stem cells: Here, there, everywhere?</A> by Connie J Eaves, <EM>Nature</EM> 2008(Dec 4); 456(7222), 581-2 [<A HREF="http://www.ncbi.nlm.nih.gov/pubmed/19052611" REL="nofollow">PubMed Citation</A>]. Excerpt:<BR/><BR/><EM>Can every tumour cell propagate human cancers or is this property exclusive to an elite subset? Findings are divided. The latest set shows that — depending on circumstances — both perspectives can be correct</EM>.Jim Tillhttps://www.blogger.com/profile/02092503335133096747noreply@blogger.com