Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours are hierarchically organized and sustained by a distinct subpopulation of CSCs. Direct evidence for the CSC hypothesis has recently emerged from mouse models of epithelial tumorigenesis, although alternative models of heterogeneity also seem to apply. The clinical relevance of CSCs remains a fundamental issue but preliminary findings indicate that specific targeting may be possible.This review is currently available free as a special feature to registered visitors to Nature Reviews Cancer. Registration is also free.
Thursday, September 25, 2008
Cancer stem cells in solid tumours: a review
Cancer stem cells in solid tumours: accumulating evidence and unresolved questions. Jane E Visvader & Geoffrey J Lindeman, Nature Reviews Cancer 2008(Oct); 8(10): 755-68. Abstract: