CSC news roundup 2010-02-28

• Tumor initiation via loss of cell contact inhibition versus Ras mutation: Do all roads lead to EMT? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bIYZjW


• CD133+ cells are more resistant to anticancer drugs than CD133- cells in neuroblastoma cell lines [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bCJKkI


• Breast cancer chemoresistance: Emerging importance of CSC [FriendFeed entry][ResearchGATE entry][PubMed citation] http://bit.ly/cmgfj4


• Neoplastic stem cells: Current concepts and clinical perspectives [Connotea bookmark][PubMed citation] http://bit.ly/9cRlm2


• Nature Methods: Renaissance of classical pathology? Autofluorescence helps identify CSC in glioma [FriendFeed entry][Connotea bookmark][PubMed citation] http://ow.ly/1ag7d


• New tool illuminates connections between stem cells and cancer [FriendFeed entry] http://bit.ly/9GLmQC


• ALDH Associated With Worse Overall Survival in Patients With Pancreatic Adenocarcinoma [FriendFeed entry][News release][PubMed citation] http://bit.ly/982S5B


• ABCG2: a potential marker of stem cells and novel target in stem cell and cancer therapy [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/clJSiU


• Induction of cell cycle entry eliminates human leukemia stem cells in a mouse model of AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9A2kHC


• Radiation Resistance of CSC - The 4R's of Radiobiology Revisited [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ddLt3N


• Evaluation of the frequency of putative prostate CSC in primary and metastatic prostate cancer [FriendFeed entry][PubMed citation] http://bit.ly/dba5IN


• Immunobiological Characterization of CSC Isolated from Glioblastoma Patients [FriendFeed entry][PubMed citation] http://bit.ly/9t2ReY


• Circulating tumor cells with a putative stem cell phenotype in peripheral blood of patients with breast cancer [PubMed citation] http://bit.ly/d17EGn


• Side population and cancer stem cells: therapeutic implications [PubMed citation] http://bit.ly/ceNr2Y


• PTEN is a tumor suppressor in CML stem cells and BCR-ABL-induced leukemias in mice [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c9VQTa


• Pancreatic cancer stem cells: new understanding of tumorigenesis, clinical implications [PubMed citation] http://bit.ly/agqb1E


• Targeting Cancer Stem Cells: Therapeutic Strategies and Pipeline Developments (Content, Jan 2010) [FriendFeed entry][BioPortfolio] http://bit.ly/cZzr3R


• Short (<2 min) video about researching pancreatic CSC at UCLA [FriendFeed entry] http://ow.ly/16NCQ


• Lecture: Max Wicha – The CSC hypothesis: biological and clinical implications (57 min) [FriendFeed entry] http://bit.ly/dhKdGD

Targeting A20 Decreases Glioma SC Survival and Tumor Growth

Targeting A20 Decreases Glioma Stem Cell Survival and Tumor Growth by Anita B Hjelmeland and 10 co-authors, including Jeremy N Rich, PLoS Biol 2010(Feb 23); 8(2): e1000319 [FriendFeed entry][Connotea bookmark].

For a news release about this publication, see: Researchers identify a potential therapeutic target for brain cancer, EurekAlert, February 22, 2010. First paragraph:

Researchers at the Cleveland Clinic report the identification of a protein that is highly expressed in a subgroup of glioblastoma brain tumor cells and show that depletion of this protein increases the survival of mice with these tumors. This work will be published in the online open-access journal PLoS Biology.

Progression of primary tumours and metastases

Parallel progression of tumour and metastases by Serge Koscielny and Maurice Tubiana, Nat Rev Cancer 2010(Feb); 10(2): 156 [PubMed citation]. Commentary on an opinion article: Parallel progression of primary tumours and metastases by Christoph Klein, Nat Rev Cancer 2009(Apr); 9(4): 302-12 [PubMed citation]. An excerpt from the full text of the commentary:

[Data are presented that] are consistent with the linear progression model when it is assumed that there are two types of cells in tumours: those that can initiate metastases (metastasis-forming cells (MFCs)), which probably derive from tumour stem cells[ref 7] and those that probably cannot initiate metastasis because their proliferative ability is limited[refs 7,8,9].

Response to the commentary: Tumour cell dissemination and growth of metastasis by Christoph A Klein, Nat Rev Cancer 2010(Feb); 10(2): 156. Excerpt from the full text of the response:

Finally, the authors declare that the parallel progression model is incompatible with the cancer stem cell hypothesis. As defined above, parallel progression does not address this issue.

The 'linear progression model' described by Christoph Klein "places major evolutionary events in the primary tumour and late dissemination of fully malignant cells that subsequently grow to manifest metastases". In the 'parallel progression model', there is "early dissemination of tumour cells from the primary tumour and ectopic selective adaptation (which is associated with the emergence of genomes fully able to form metastases)" (see Christoph Klein's response).

CSC news roundup 2010-02-13

• ABCG5-positivity in tumor buds is an indicator of poor prognosis in node-negative colorectal cancer patients [FriendFeed entry][Connotea bookmark][PubMed citation][Full text PDF] http://bit.ly/94fqTs


• Good cells gone bad: the cellular origins of cancer [Connotea bookmark][PubMed citation] http://bit.ly/crHb0Y


• Targeted Cancer Stem Cell Therapies Start with Proper Identification of the Target - Letter [Connotea bookmark][PubMed citation] and Response [Connotea bookmark][PubMed citation]


• Transcriptional Profiles of CD133+ and CD133- Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin [Connotea bookmark][PubMed citation] http://bit.ly/b255Ec


• ALDH1A1(+) cell population enriched in tumor-initiating cells, associated with progression of bladder cancer [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bDj1yx


• Association of stem cell marker CD133 expression with dissemination of glioblastomas [Sciencia entry][Connotea bookmark][PubMed citation] http://bit.ly/b3azCE


• NO signaling in perivascular niche promotes stem-like characteristics in glioma cells [FriendFeed entry][PubMed citation] http://bit.ly/c8Enie


• TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/bivZQu


• Selective targeting of radiation-resistant tumor-initiating cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/chw0Fi


• CSC from colorectal cancer-derived cell lines [FriendFeed entry][News release][PubMed citation] http://bit.ly/bDxxnM


• Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia SC [FriendFeed entry][News release] http://bit.ly/9g8yUJ


• Heterogeneity for Stem Cell-Related Markers According to Tumor Subtype and Histologic Stage in Breast Cancer [Connotea bookmark][PubMed citation] http://bit.ly/aVE3SF


• Hypothesis: co-existing active-quiescent pools of CSC sub-populations? [FriendFeed entry][PubMed citation] http://bit.ly/acMHpi


• Disarming Specialized SC Might Combat Deadly Ovarian Cancer [FriendFeed entry][PubMed citation] http://bit.ly/cTpNTM


• A seminal finding for prostate cancer? [Article summary][Topsy entry][PubMed citation] http://bit.ly/7jCq2n


• Dissecting Cancer Stem Cell Theories [FriendFeed entry] http://bit.ly/9oilZA

Review about retroviral-induced leukemogenesis and the CSC hypothesis

Hematopoietic stem cells and retroviral infection by Prabal Banerjee, Lindsey Crawford, Elizabeth Samuelson and Gerold Feuer, Retrovirology 2010(Feb 4); 7(1): 8 [Epub ahead of print][Connotea bookmark][[FriendFeed entry][PubMed Citation][Full text (PDF)].

Includes sections on Leukemia Stem Cells/Cancer Stem Cells (LSC/CSC) and on The Cancer Stem Cell Hypothesis.