CSC news roundup 2010-03-27

• The Wnt/β-Catenin Pathway Is Required for the Development of Leukemia Stem Cells in AML [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/cfLPyK


• Expansion of CD133+ colon cancer cultures retaining stem cell properties to enable cancer stem cell target discovery [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9NLTZ8


• Loss of heterozygosity of the tumor suppressor gene Tg737 in the side population cells of hepatocellular carcinomas is associated with poor prognosis [FriendFeed entry][PubMed citation] http://bit.ly/dCQGYL


• Cancer Stem Cells: The Final Frontier for Glioma Virotherapy [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/c8GeYb


• MUC4 down-regulation reverses chemoresistance of pancreatic cancer stem/progenitor cells and their progenies [FriendFeed entry][ResearchGATE entry][Connotea bookmark][PubMed citation] http://bit.ly/cvcfX7


• Expression of Pluripotent Stem Cell Reprogramming Factors by Prostate Tumor Initiating Cells [FriendFeed entry][PubMed citation] http://bit.ly/9jtqLK


• Molecular signaling of the epithelial to mesenchymal transition in generating and maintaining cancer stem cells [FriendFeed entry] [ResearchGATE entry][PubMed citation] http://bit.ly/9xWial


• Cancer stemness and metastasis: Therapeutic consequences and perspectives [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9s0W14


• Gene-expression profiles, tumor microenvironment, and cancer stem cells in breast cancer: Latest advances towards an integrated approach [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/dgqE0n


• Molecular biology of breast cancer stem cells: Potential clinical applications [FriendFeed entry][PubMed citation] http://bit.ly/as3m3j


• In Situ Identification of Putative Cancer Stem Cells by Multiplexing ALDH1, CD44, and Cytokeratin Identifies Breast Cancer Patients with Poor Prognosis [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9rXuWC


• c-Jun Induces Mammary Epithelial Cellular Invasion and Breast Cancer Stem Cell Expansion [FriendFeed entry][PubMed citation] http://bit.ly/aInNB2


• The Utility and Limitations of Neurosphere Assay, CD133 Immunophenotyping and Side Population Assay in Glioma Stem Cell Research [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9O4PtL


• Methods of assaying sensitivity of cancer stem cells to therapeutic modalities (USPTO Application) [FriendFeed entry][FreshPatents entry] http://bit.ly/dcWhtJ


• Cancer Stem Cells [Book and Media Reviews] JAMA 2010(Mar 17);303(11):1098 [FriendFeed entry][Book contents] http://bit.ly/9PY8xP


• Challenges in the development of future treatments for breast cancer stem cells (OA review) [FriendFeed entry] http://bit.ly/9DGutB

CSC news roundup 2010-03-16

• microRNA-34a is tumor suppressive in brain tumors and glioma stem cells [FriendFeed entry][CSC News post][PubMed citation] http://bit.ly/a5onzu


• Enrichment for breast cancer cells with stem/progenitor properties by differential adhesion [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/ceskEY


• miR-29a initiates AML by converting myeloid progenitors into self-renewing leukemia SC? [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9sM8Mw


• Oncolytic viral purging of leukemic hematopoietic stem and progenitor cells with Myxoma virus [FriendFeed entry][PubMed citation] http://bit.ly/c0SRla


• @sciclips MicroRNA as a target for the inhibition of glioblastoma stem cells [FriendFeed entry] http://bit.ly/cvXSwu


• @sciclips The most complete systems biology study of cancer stem cell (CSC) differentiation to date [FriendFeed entry][PubMed citation] http://bit.ly/cBe4D3


• Presentations on Geron’s Telomerase Inhibitor At AACR Special Conference (Business Wire) [FriendFeed entry] http://bit.ly/cFmyWp


• CD24+ cells from hierarchically organized ovarian cancer are enriched in cancer stem cells [FriendFeed entry][Connotea bookmark][PubMed citation] http://bit.ly/9ZmKqT


• Targeting leukemia stem cells (by inducing them to divide) [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/aVquQk


• RT @cancer_news: [Reflection and Reaction] HER2 as a cancer stem-cell target [FriendFeed entry][PubMed citation] http://is.gd/9udQM


• Evidence for self-renewing lung CSCs & their implications [FriendFeed entry][Connotea bookmark][ResearchGATE entry][PubMed citation] http://bit.ly/cje8cc


• Cancer as a reprogramming-like disease: Implications in tumor development and treatment [Connotea bookmark][PubMed citation] http://bit.ly/csHdxT


• RT: @cancer_news Identification of the cell lineage at the origin of basal cell carcinoma [FriendFeed entry][PubMed citation] http://is.gd/9sT10


• Alpha-fetoprotein producing cells act as cancer progenitor cells in human cholangiocarcinoma [FriendFeed entry][CiteULike entry][PubMed citation] http://bit.ly/bp6dnS


• Efficacious Immune Therapy in CML Recognizes Antigens That Are Expressed on CML Progenitor Cells [FriendFeed entry][PubMed citation] http://bit.ly/briNv0


• Notch-Blocking Drugs Kill Brain Cancer Stem Cells http://bit.ly/bQqs4f about [PubMed citation] http://bit.ly/cJZ5e3


• Universal cancer vaccine containing cancer stem cells [FriendFeed entry] http://bit.ly/bDn5R8


• Dock-and-lock (DNL) anti-cancer vaccine for multiple myeloma cancer stem cells [FriendFeed entry] http://bit.ly/csGN8N

Conditioned medium induces generation of side population cells

Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment by Jun-Xia Cao and 8 co-authors, including Quentin Liu, BMC Cancer 2010(Feb 25); 10: 68 [PubMed citation][Full text via PMC][Full text from journal (via Libre OA)]. Conclusion section of the Abstract:

To our knowledge, this is the first study to demonstrate that non-SP single-clone cells can be induced to generate a SP phenotype when they are cultured with conditioned medium of macrophage-like cells, which is associated with the reactivation of pluripotency-associated genes.

MicroRNA-34a is a potential therapeutic agent for glioma SC?

See the open-access article: microRNA-34a is tumor suppressive in brain tumors and glioma stem cells by Fadila Guessous and 7 co-authors, including Roger Abounader, Cell Cycle 2010(Mar 18); 9(6) [Epub ahead of print][FriendFeed entry][PubMed citation]. Last 3 sentences of the Abstract:

The new data show that miR-34a expression inhibits various malignancy endpoints in glioma stem cells. Importantly, they also show for the first time that miR-34a expression induces glioma stem cell differentiation. Altogether, the data suggest that miR-34a is a tumor suppressor and a potential potent therapeutic agent that acts by targeting multiple oncogenic pathways in brain tumors and by inducing the differentiation of cancer stem cells.