Conditioned medium induces generation of side population cells

Pluripotency-associated genes in human nasopharyngeal carcinoma CNE-2 cells are reactivated by a unique epigenetic sub-microenvironment by Jun-Xia Cao and 8 co-authors, including Quentin Liu, BMC Cancer 2010(Feb 25); 10: 68 [PubMed citation][Full text via PMC][Full text from journal (via Libre OA)]. Conclusion section of the Abstract:

To our knowledge, this is the first study to demonstrate that non-SP single-clone cells can be induced to generate a SP phenotype when they are cultured with conditioned medium of macrophage-like cells, which is associated with the reactivation of pluripotency-associated genes.