Tuesday, February 17, 2009

Elimination of CSC in a mouse model of CML

Targeting a chronic problem: elimination of cancer stem cells in CML by Claus Nerlov, EMBO J 2009(Feb 4); 28(3): 167-8 [PubMed Citation][Openly accessible full text][Version in PMC]. First paragraph:
The eradication of tumours by targeting malignant stem cell populations, or cancer stem cells (CSCs), is a promising new strategy for cancer treatment. In a paper published in a recent issue of The EMBO Journal, pharmacogenetic evidence has been obtained that this is indeed feasible in a mouse model of human chronic myeloid leukaemia. These and further similar experiments will be essential to determine the validity and practical usefulness of the CSC hypothesis.
This article is a commentary about: Cancer induction by restriction of oncogene expression to the stem cell compartment by María Pérez-Caro and 12 co-authors, including Isidro Sánchez-García, EMBO J 2009(Jan 7); 28(1): 8-20 [Epub 2008(Nov 27)][PubMed Citation][Openly accessible full text][Version in PMC]. Excerpt from the last paragraph of the Discussion section of the full text:
The data presented here further show for the first time the in vivo physiological relevance of the CSC suppression using a model system representing in vivo biology of the human CML disease. .....

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