Thursday, February 5, 2009

Pointers for future research on CSC

Looking ahead in cancer stem cell research by John E Dick, Nat Biotechnol 2009(Jan); 27(1): 44-6 [PubMed Citation]. Leading sentence:
The history of the stem cell field offers pointers for future research on cancer stem cells.
The full text is publicly accessible. Excerpts:
Since the beginning of the era inaugurated by the great experimental pathologists, microscopic examination has revealed that many tumors, be they liquid or solid, exhibit morphologic heterogeneity. Tumors are also heterogeneous functionally, as demonstrated most dramatically by studies in which murine or human tumors were re-transplanted into syngeneic or xenogeneic immune-compromised recipients. Remarkably, such experiments have also included human autotransplants. The collective conclusion from these studies was that tumor re-initiation is variable and often rare, requiring 103 to 107 cells.
Ultimately, the relevance of the CSC model will be determined by clinical data.
See also:

The CSC hypothesis: recalling some history (December 30, 2008).

Tumorigenic cells not rare in human melanoma (December 3, 2008).


  1. See also: "Host resistance to cancer. Clinical experiments by homotransplants, autotransplants and admixture of autologous leucocytes", by Alexander Brunschwig, Chester M Southam and Arthur G Levin, Ann Surg 1965(Sep); 162(3): 416-25 [PubMed Citation][Full text via PubMed Central].

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  3. See also: John Dick: careful assays for cancer stem cells by Monya Baker, Nature Reports Stem Cells, March 26, 2009. (The full text is publicly accessible).

  4. Jim Till and Dear all,

    I found this website extremely interesting and informative. Thanks for updates on latest articles on CSCs. I am wondering can anyone suggest me an assay to identify asymmetric and symmetrically dividing CSCs. I am interested in exploring NSCL cancer cell line models to see if A becomes A+A (two daughter CSCs) or A becomes A+B(one CSC and other differentiating cell) or A becomes B+B (two daughter differentiating cells). Thanks a lot and appreciate the efforts of this blog organizers and Jim Till. -Dhanvanthri S. Deevi, New York, USA