CONCLUSION: The fact that a higher percentage CD133+ cells were strongly associated with a poorer prognosis in patients with locally advanced colon cancer implicated that CD133+ cancer cells contribute to the tumor progression, and the overpopulation hypothesis of cancer stem cell seems reasonable.
Tuesday, July 28, 2009
CD133 and poorer prognosis in locally advanced colon cancer
Higher percentage of CD133+ cells is associated with poor prognosis in colon carcinoma patients with stage IIIB by Chun-Yan Li and 11 co-authors, including Xiao-Shi Zhang, J Transl Med 2009(Jul 7); 7: 56. [Full text via Libre OA][PMC version of the full text][PubMed Abstract] Final paragraph of the Abstract: