Human leukemia stem cells escape detection by co-opting a protective molecular badge used by normal blood stem cells to migrate safely within the body, according to a pair of studies by researchers at Stanford University Medical School.See also: Molecule Helps Leukemia Cells Hide From Immune System, Drugs.com, July 23, 2009. First sentence:
Leukemia stem cells cleverly cloak themselves to avoid detection by a person's immune system, according to a pair of studies by researchers at Stanford University Medical School.And: Leukemia cells evade immune system by mimicking normal cells, Stanford studies show, EurekAlert, July 23, 2009.
The two articles upon which the news releases are based:
1) CD47 Is Upregulated on Circulating Hematopoietic Stem Cells and Leukemia Cells to Avoid Phagocytosis by Siddhartha Jaiswal, Catriona H M Jamieson and 7 co-authors, including Irving L Weissman, Cell 2009(Jul 23); 138(2): 271-85. [PubMed Citation].
2) CD47 Is an Adverse Prognostic Factor and Therapeutic Antibody Target on Human Acute Myeloid Leukemia Stem Cells by Ravindra Majeti and 7 co-authors, including Irving L Weissman, Cell 2009(Jul 23); 138(2): 286-99. [PubMed Citation][FriendFeed entry].