Some breast cancers are thought to arise from mammary stem cells that mutate, but a study published in this week's Nature Medicine indicates that luminal cells that line the mammary ducts may also be tumor progenitors.This Research Highlight is based on the publication: Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers by Elgene Lim and 20 co-authors, including kConFab, Jane E Visvader and Geoffrey J Lindeman, Nat Med 2009(Aug 2) [Epub ahead of print]. Final sentence of the PubMed Abstract:
Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors.See also: Breast cancer discovery heralds diagnosis hope by Nick Miller, theage.com.au, August 3, 2009. Excerpt:
The breakthrough research came from the study of a unique collection of breast cancer tissue donated by Australian women.And: Stem cell 'daughters' lead to breast cancer, EurekAlert, August 2, 2009. [FriendFeed entry]. Note to anyone who might find this title confusing: The word 'daughters' refers to cells that are produced by stem cells, not to the 'daughters' of patients!