A new progenitor cell population in breast cancer,
Nature Asia-Pacific, August 3, 2009. First paragraph:
Some breast cancers are thought to arise from mammary stem cells that mutate, but a study published in this week's Nature Medicine indicates that luminal cells that line the mammary ducts may also be tumor progenitors.
This Research Highlight is based on the publication:
Aberrant luminal progenitors as the candidate target population for basal tumor development in BRCA1 mutation carriers by Elgene Lim and 20 co-authors, including
kConFab,
Jane E Visvader and
Geoffrey J Lindeman,
Nat Med 2009(Aug 2) [Epub ahead of print]. Final sentence of the
PubMed Abstract:
Our findings suggest that an aberrant luminal progenitor population is a target for transformation in BRCA1-associated basal tumors.
See also:
Breast cancer discovery heralds diagnosis hope by Nick Miller,
theage.com.au, August 3, 2009. Excerpt:
The breakthrough research came from the study of a unique collection of breast cancer tissue donated by Australian women.
And:
Stem cell 'daughters' lead to breast cancer,
EurekAlert, August 2, 2009. [
FriendFeed entry].
Note to anyone who might find this title confusing: The word 'daughters' refers to cells that are produced by stem cells, not to the 'daughters' of patients!
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For an interesting commentary, see: Finding the cell that fuels the tumour by Monya Baker, Nature Reports Stem Cells, August 6, 2009.
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