Blog post about the complexity of CSC

Complexity of cancer stem cells by Alexey Bersenev, Hematopoiesis, May 6, 2009. [Twitter link to blog post] Final paragraph:

But not everything about CSC is so pessimistic. We know many good examples of successful targeting and eradication in tumors where the CSC model could be applied. We still have a lot of ways, other than surface molecules and signaling pathways, to target them. We are still developing a models to validate the concept. We can see clinical relevance and significance of CSC. Field is developing tremendously right now and a model is in the making.

… debating the existence of CSCs or their frequency is not a particularly useful exercise, and the scientific community would be well served to move beyond these issues. Rather, the more pertinent question is whether studying and targeting CSC is important for developing better forms of therapy. The answer to that query seems somewhat less clear.
Craig Jordan (U of Rochester)